Background:

The Organ Manufacturing and Regenera.ve Medicine Project will be focused ini.ally on the heart and heart disease. Cardio Vascular Diseases (CVD) are the number one cause of death globally: more people die annually from CVDs than from any other cause. An es.mated 17.3 million people died from CVDs in 2008, represen.ng 30% of all global deaths. Of these deaths, an es.mated 7.3 million were due to coronary heart disease and 6.2 million were due to stroke. By 2030, almost 23.6 million people will die from CVDs, mainly from heart disease and stroke. These are projected to remain the single leading causes of death. Addi.onally, dozens of drugs and billions of dollars have been spent comba.ng heart disease.

Regenera.ve medicine is a young but promising research field. Regenera.ve medicine has already proven beneficial in pa.ents with heart disease. When the heart becomes diseased or damaged it gets weakened and is unable to pump the volume of blood necessary to the rest of the body. Some.mes the heart stops all together resul.ng in a heart aFack. Stem cells have been proven to help rebuild a damaged or diseased heart but some.mes the heart is so damaged that a transplant is called for. If a brand new heart could be manufactured using the pa.ent’s cells, this kind of transplant would be more successful than ar.ficial or donor heart transplants are today. The goals of the Organ Manufacturing project are to harness the healing power of stem cells, and to perfect organ manufacturing and transplanta.on in humans. The Cure Is Now will begin with the heart and then move to other vital organs such as the liver, lungs, kidneys etc.

Complica.ons have been regenerated vasculature, successful bioreactor technology and transplanta.on technique.

Approach:

The ini.al approach will be to harvest stem cells in the least invasive way possible and then transform them into cardiac stem cells. Safe and effec.ve Injec.on of these cells into or next to the heart in such away that the stem cells benefit the injured heart will be perfected.

The next step will be to grow a viable heart in the lab followed by transplanta.on into humans.

The Cure Is Now Organ Manufacturing and Regenera.ve Medicine team will eventually move their focus to other vital organs.

Requirements:

This project will various kinds of studies. Inpa.ent and outpa.ent facili.es will be required among other types of facili.es. Microscopes, cell medium and pathology facili.es would be required.  Organ regenera.on and transplanta.on into humans will require decellularized organ scaffolds, stem cell harves.ng and growth equipment in a sterile environment, in vivo or in vitro bio reactors will be required and out and inpa.ent facili.es will be u.lized.

Es1mated costs:

Injectable Stem Cell Pilot project Organ Regenera.on and transplanta.on project Pilot The goal with these projects will be to bring this model into humans.

Staff salaries:

$440,000/year
Research materials: $100,000/year
Reagents: $100,000/year
Regenera.on Apparatus: $200,000/year
One-­‐off expenses: Computers: $105,000
Equipment (hoods, etc.): $550,000


Project Annual Total: $1,495,000